Ethnic, clinical and immunological factors in systemic lupus erythematosus and the development of lupus nephritis: results from a multi-ethnic New Zealand cohort
Identifieur interne : 001B50 ( Main/Exploration ); précédent : 001B49; suivant : 001B51Ethnic, clinical and immunological factors in systemic lupus erythematosus and the development of lupus nephritis: results from a multi-ethnic New Zealand cohort
Auteurs : F. Burling [Nouvelle-Zélande] ; J. Ng [Nouvelle-Zélande] ; H. Thein [Nouvelle-Zélande] ; J. Ly [Nouvelle-Zélande] ; M. R. Marshall [Nouvelle-Zélande] ; P. Gow [Nouvelle-Zélande]Source :
- Lupus [ 0961-2033 ] ; 2007-10.
English descriptors
- Teeft :
- Active lupus nephritis, American college, Anaemia, Anticardiolipin antibodies, Arthritis rheum, Auckland, Burling, Caucasian, Chinese patients, Chronic kidney disease, Clinical manifestations, Clinical presentation, Cohort, Cutaneous, Cutaneous vasculitis, Disease activity, Dsdna, Erythematosus, Ethnicity, Family history, Hazard ratio, Hypertension, Hypocomplementaemia, Independent risk factors, Logistic regression, Lupus, Lupus anticoagulant, Lupus lupus nephritis, Lupus nephritis, Lupus patients, Maori, Maori patients, Multivariate analysis, Nephritis, Normal range, Odds ratio, Patient notes, Predictor, Renal, Renal disease, Rheum, Risk factors, Serositis, Systemic, Systemic lupus erythematosus, Univariate analysis, Upper limit, Vasculitis.
Abstract
The aim of this study was to identify risk factors for lupus nephritis including clinical, laboratory, and ethnic factors in a cohort of lupus patients in New Zealand. A retrospective study of patients from two teaching hospitals in Auckland, New Zealand. Patients were selected if they had attended as either an inpatient, or a rheumatology outpatient between 2000 and 2005. 170 patients had SLE according to ACR classification. Lupus nephritis (LN) was diagnosed according to ACR criteria. Clinical, laboratory, and ethnic data were gathered from the patient notes. Twenty-four patients had LN at diagnosis and 32 patients developed LN after diagnosis. LN was associated with serositis (P = 0.008), cutaneous vasculitis (P = 0.026), anaemia (P = 0.005), CRP elevation >6 months (P < 0.001), hypocomplementaemia >6 months (P < 0.0001). Patients with elevated doublestranded DNA (dsDNA) (>5 × normal) were more likely to develop type IV LN (P = 0.0096). Forty-one percent of patients were Caucasian, 12% Maori, 23% Pacific People, 16% Asian, 6% Indian. Maori patients with SLE (odds ratio (OR) = 8.47, 95% confidence interval (CI) = 2.11—33.96, P = 0.002), and Pacific People (OR = 3.11, 95% CI = 1.29—11.48, P = 0.014) had increased risk for developing LN. Anaemia at presentation (hazard ratio (HR) 3.2, 95% CI = 1.4—7.1, P = 0.004), and low complement >6 months (HR = 3.4, 95% CI = 1.4—8.7, P = 0.008) were independent risk factors for developing LN after SLE diagnosis. In New Zealand, Pacific People and Maori patients with SLE have a higher incidence of LN, and patients with anaemia and hypocomplementaemia are more likely to develop LN after diagnosis. Patients with high dsDNA levels are more likely to develop Type IV lupus nephritis. Lupus (2007) 16, 830—837.
Url:
DOI: 10.1177/0961203307080225
Affiliations:
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A retrospective study of patients from two teaching hospitals in Auckland, New Zealand. Patients were selected if they had attended as either an inpatient, or a rheumatology outpatient between 2000 and 2005. 170 patients had SLE according to ACR classification. Lupus nephritis (LN) was diagnosed according to ACR criteria. Clinical, laboratory, and ethnic data were gathered from the patient notes. Twenty-four patients had LN at diagnosis and 32 patients developed LN after diagnosis. LN was associated with serositis (P = 0.008), cutaneous vasculitis (P = 0.026), anaemia (P = 0.005), CRP elevation >6 months (P < 0.001), hypocomplementaemia >6 months (P < 0.0001). Patients with elevated doublestranded DNA (dsDNA) (>5 × normal) were more likely to develop type IV LN (P = 0.0096). Forty-one percent of patients were Caucasian, 12% Maori, 23% Pacific People, 16% Asian, 6% Indian. Maori patients with SLE (odds ratio (OR) = 8.47, 95% confidence interval (CI) = 2.11—33.96, P = 0.002), and Pacific People (OR = 3.11, 95% CI = 1.29—11.48, P = 0.014) had increased risk for developing LN. Anaemia at presentation (hazard ratio (HR) 3.2, 95% CI = 1.4—7.1, P = 0.004), and low complement >6 months (HR = 3.4, 95% CI = 1.4—8.7, P = 0.008) were independent risk factors for developing LN after SLE diagnosis. In New Zealand, Pacific People and Maori patients with SLE have a higher incidence of LN, and patients with anaemia and hypocomplementaemia are more likely to develop LN after diagnosis. Patients with high dsDNA levels are more likely to develop Type IV lupus nephritis. Lupus (2007) 16, 830—837.</div></front></TEI><affiliations><list><country><li>Nouvelle-Zélande</li></country></list><tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Burling, F" sort="Burling, F" uniqKey="Burling F" first="F." last="Burling">F. Burling</name></noRegion><name sortKey="Gow, P" sort="Gow, P" uniqKey="Gow P" first="P." last="Gow">P. Gow</name><name sortKey="Ly, J" sort="Ly, J" uniqKey="Ly J" first="J." last="Ly">J. Ly</name><name sortKey="Marshall, M R" sort="Marshall, M R" uniqKey="Marshall M" first="M. R." last="Marshall">M. R. Marshall</name><name sortKey="Ng, J" sort="Ng, J" uniqKey="Ng J" first="J." last="Ng">J. Ng</name><name sortKey="Thein, H" sort="Thein, H" uniqKey="Thein H" first="H." last="Thein">H. Thein</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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